Myphoner supports any voip softphone that is click-to-call compliant.
You can experiment with different call handlers from your preferences.
Check out the brief screencast on how to set it up:
Myphoner will try to activate the voip softphone (dialer) installed on your computer when you click a phone number (via click-to-call), so you need one installed and ready to dial real phones.
You can find a list of click-to-call compliant dialers and providers on our Cold Calling Resources page.